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課程名稱 |
生物資訊與計算分子生物學
BIOINFORMATICS AND COMPUTATIONAL MOLECULAR BIOLOGY |
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開課學期 |
99-1 |
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授課對象 |
電機資訊學院 資訊工程學研究所 |
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授課教師 |
高成炎 |
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課號 |
CSIE7726 |
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課程識別碼 |
922 U0020 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期四6,7,8(13:20~16:20) |
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上課地點 |
資310 |
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備註 |
限學士班三年級以上
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/991bioinfo_1 |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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課程概述 |
Since the structure of DNA was unraveled in 1953, molecular biology has witnessed tremendous advances. With our increasing ability to manipulate bio-molecular sequences, a huge amount of data is being generated. The computer is a natural instrument for solving molecular biology problems. Computational Molecular Biology consists of the development and use of mathematical and computer science techniques in solving problems in molecular biology. |
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課程目標 |
Since the structure of DNA was unraveled in 1953, molecular biology has witnessed tremendous advances. With our increasing ability to manipulate bio-molecular sequences, a huge amount of data is being generated. The computer is a natural instrument for solving molecular biology problems. Computational Molecular Biology consists of the development and use of mathematical and computer science techniques in solving problems in molecular biology. |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Group Project |
100% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/16 |
Introduction |
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第2週 |
9/23 |
Microarray – molecular biology and data analysis |
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第3週 |
9/30 |
BIT2010 Conference |
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第4週 |
10/07 |
Microarray – databases (hands-on practice) |
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第5週 |
10/14 |
Microarray –gene expression analysis (hands-on practice) |
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第6週 |
10/21 |
DNA sequencing technology, sequence alignment and annotation |
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第7週 |
10/28 |
Microarray – probes v. s. genes (hands-on practice) |
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第8週 |
11/04 |
Microarray – clustering (hands-on practice) |
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第9週 |
11/11 |
Mid-term: Progress Report and Discussion |
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第10週 |
11/18 |
Protein-protein interaction – evidences and prediction |
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第11週 |
11/25 |
Important databases: Gene Ontology, Pathway, Drug Bank, etc |
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第12週 |
12/02 |
Integrative platforms and tools of computational biology |
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第13週 |
12/09 |
Other significant topics: SAGE, Sequence Assembly, qPCR |
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第14週 |
12/16 |
Other significant topics: Alternative splicing, promoter analysis, SNP and DNA methylation, small RNA and gene silencing |
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第15週 |
12/23 |
Project – Problem Solving, Q&A |
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第16週 |
12/30 |
Project – Final Report |
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第17週 |
1/06 |
Project – Final Report |
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